İron Metabolism İn Pati̇ents with Impaired Thyroid Function Ti̇roi̇d Fonksi̇yon Bozukluğu Olan Hastalarda Demi̇r Metaboli̇zmasi

We aimed in this study to determine the changes due to hyperthyroidism or hypothyroidism in serum ferritin, iron, transferrin, vitamin Bn and erythrocytic parameters and to investigate the interrelationships between these parameters .Serum ferritin, iron, total iron-binding capacity (transferrin), vitamin B12, total andfree trüodothyronine (TT3 and FT3) , total andfree thyroxine (TT4 and FT4), thyroid-stimulating hormone (TSH) levels were measured in 30 patients (26 women, 4 men) with hyperthyroid; 30 patients (26 women, 4 men) with hyporthyroid and 25 healthy subjects (22 women, 3 men). Serum ferritin levels of hyperthyroid patients were higher than those of hypothyroid patients and healthy controls (p<0.05). Serum iron levels of hyperthyroid patients were only higher than those of hypothyroid patients (p<0.05). Transferrin levels were higher in ali of patients than healthy group (p<0.05). Vitamin B12 concentrations in hypothyroid patients were lower than those of hyperthyroid patients. Total and free T3 and total and free T4 levels in hyperthyroid patients were higher than those of hypothyroid patients and controls (p<0.05), but TSH levels were lower than only those of hypothyroid patients. Statistical analysis between the groups according to erythrocyte count were insignificant. The differences between haemoglobin and hematocrit levels in group of patients were also insignificant. The effects of sex, smoking status, use of salt (with or without iodine), goitrogenic food on the serum parameters were statistically investigated. Our data suggest that alterations in thyroid status produce changes in iron metabolism and vitamin B12 levels.